Enhanced delivery of mitomycin C derivatives through hairless mouse and rat skins-Reference-Cited by-同舟云学术

Enhanced delivery of mitomycin C derivatives through hairless mouse and rat skins

Published:1985-08 Issue:8 Volume:37 Page:542-544
ISSN:2042-7158
Container-title:Journal of Pharmacy and Pharmacology
language:en
Short-container-title:

Author:

Hashida M¹,Mukai E¹,Kimura T¹,Sezaki H¹

Affiliation:

1. Faculty of Pharmaceutical Sciences, Kyoto University, Kyoto, 606, Japan

Abstract

Abstract The percutaneous permeation characteristics of two lipophilic mitomycin C derivatives with aromatic moieties were determined using excised hairless mouse and rat skins and compared with those of mitomycin C (MMC). 1a-N-Benzylmitomycin C penetrated more readily through both kinds of skin than MMC without metabolic conversion. 1a-N-Benzyloxycarbonylmitomycin C effected a 4-fold increase in the delivery of MMC through the rat skin and was completely converted to MMC by an enzyme in rat skin. However, saturation of the metabolic conversion activity was observed in the hairless mouse skin.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

Link

http://academic.oup.com/jpp/article-pdf/37/8/542/37532972/j.2042-7158.1985.tb03063.x.pdf

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