Affiliation:
1. Department of Pharmacy, Chelsea College of Science and Technology (University of London), Manresa Road, London, S.W.3, England
Abstract
Abstract
The kinetics of absorption, metabolism, and excretion of (+)-amphetamine and (+)-methylamphetamine, after oral administration of “free” dosage forms to man, under controlled acidic urine conditions, have been examined using an electronic analogue computer. This device has also been used to determine the in vivo rate of release of the drugs from hard gelatin capsule dosage forms and prolonged-release preparations. In vivo drug release from the prolonged-release preparations was correlated with in vitro drug release data.
Publisher
Oxford University Press (OUP)
Subject
Pharmaceutical Science,Pharmacology
Cited by
21 articles.
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