Affiliation:
1. Department of Pharmacy, Chelsea College of Science and Technology (University of London), London S.W.3, England
Abstract
Abstract
After administration of methadone to man, only two basic urinary excretion products were detected, these were unchanged drug and 2-ethyl-1, 5-dimethyl-3, 3-diphenyl-1-pyrroline. The hydriodide of the latter was synthesized and its endocyclic alkene structure was confirmed from infrared and nuclear magnetic resonance spectral data. This compound was shown to be identical with the hydriodide of the basic product formed by reaction of 1, 5-dimethyl-3, 3-diphenylpyrrolid-2-one with ethyl-lithium.
Publisher
Oxford University Press (OUP)
Subject
Pharmaceutical Science,Pharmacology
Cited by
98 articles.
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