Affiliation:
1. Level 8, Clinical Sciences Building, St James's University Hospital, Leeds LS9 7TF, UK
Abstract
Abstract
5−HT3 receptors are ubiquitous in the enteric, sympathetic, parasympathetic and sensory nervous systems and in the central nervous system (CNS) (Kilpatrick et al 1990). In man 5−HT3 receptors are mainly situated on enterochromaffin cells in the gastrointestinal mucosa, which are innervated by vagal afferents (Reynolds et al 1989), and the area postrema of the brain stem, which forms the chemoreceptor trigger zone. Ondansetron is a selective antagonist at 5−HT3 receptors. It is 100 times more potent than metoclopramide at this site (Tyers 1992). It shows limited binding to other receptors and has a wide therapeutic window. Ondansetron is a useful antiemetic which probably has both central and peripheral actions in patients undergoing radiotherapy, cytotoxic chemotherapy or general anaesthesia (Naylor & Rudd 1992). This paper reviews the pharmacokinetics of ondansetron in health and disease to provide information for clinicians; it might alter prescribing and alert them to possible drug interactions.
Publisher
Oxford University Press (OUP)
Subject
Pharmaceutical Science,Pharmacology
Reference56 articles.
1. Antiemetic efficacy of ondansetron in long term therapy;Adler;Eur. J. Cancer,1991
2. Population pharmacokinetics of intravenous and oral ondansetron in patients with systemic lupus erythematosus (SLE);Amantea;J. Clin Pharmacol.,1993
3. The pharmacokinetics of ondansetron after intravenous injection in healthy volunteers phenotyped as poor or extensive metabolizers of debrisoquine;Ashforth;Br. J. Clin. Pharmacol.,1994
4. Clinical pharmacology of ondansetron in postoperative nausea and vomiting;Baber;Eur. J. Anaesthesiol.,1992
5. The clinical pharmacology of ondansetron;Blackwell;Eur. J. Clin. Oncol.,1989
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