The antitussive actions of the drug Ru 20201 given as an aerosol to cats-Reference-Cited by-同舟云学术

The antitussive actions of the drug Ru 20201 given as an aerosol to cats

Published:1978-09 Issue:1 Volume:30 Page:563-565
ISSN:2042-7158
Container-title:Journal of Pharmacy and Pharmacology
language:en
Short-container-title:

Author:

Korpas J¹,Nosalova G¹,Widdicombe J G²

Affiliation:

1. Department of Pathological Physiology and Pharmacology, Medical Faculty, Comenius University, Martin, CSSR

2. Department of Physiology, St. George's Hospital Medical School, Tooting, London SW17 0RE, UK

Abstract

Abstract The effect of the drug Ru 20201 (1,2,3,4,4a,9b-hexahydro-8,9b-dimethyl-4-[3-(4-methylpiperazin-1-yl)propionamido]dibenzofuran-3-one upon mechanically-evoked cough from the laryngopharyngeal and tracheobronchial areas in nine unanaesthetized cats has been examined. Inhalation of 2 ml of an aerosol of a 10% solution in water suppressed coughing for 30 min. The effect was greatest on the number of cough efforts. The expiratory component of cough was suppressed more than was the inspiratory one. The effect was greater on cough from the laryngopharyngeal than from the tracheobronchial area.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

Link

http://academic.oup.com/jpp/article-pdf/30/1/563/37759324/j.2042-7158.1978.tb13324.x.pdf

Reference15 articles.

1. The choice of antitussive agents;Bickerman,1960

2. The Effect of Anaesthesia of the Airway in Dog and Man: A Study of Respiratory Reflexes, Sensations and Lung Mechanics

3. Inhibition of respiratory reflexes by local anesthetic aerosols in dogs and rabbits

4. Über das Absetzen kleiner, in der Luft suspendierter Teilchen in der menschlichen Lunge bei der Atmung

Cited by 4 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. The effect of nedocromil sodium, sodium cromoglycate and codeine phosphate on citric acid-induced cough in dogs;British Journal of Pharmacology;1988-03

2. The Chemistry of Pyrazolopyridines;Advances in Heterocyclic Chemistry;1984

3. ANTITUSSIVE EFFECT OF RU-20201 - CENTRAL AND PERIPHERAL ACTIONS;JPN J PHARMACOL;1984

4. Antitussive Effect of RU-20201—Central and Peripheral Actions;Japanese Journal of Pharmacology;1984