Skin‐centered strategies in food allergy prevention

Author:

Braun Camille123,Coutier Laurianne24,Bégin Philippe15,Nosbaum Audrey36

Affiliation:

1. Section of Allergy and Clinical Immunology, Department of Pediatrics Centre Hospitalier Universitaire Sainte‐Justine Montreal Quebec Canada

2. Department of Pediatrics, Pneumology, Allergy, Cystic Fibrosis Hôpital Femme Mère Enfant Bron France

3. Centre International de Recherche en Infectiologie, INSERM U1111, CNRS UMR 5308, Université Lyon 1 Lyon France

4. INSERM U1028 CNRS UMR 5292, Université Lyon 1 Lyon France

5. Department of Medicine, Section of Allergy and Clinical Immunology Centre Hospitalier de l'Université de Montréal Montreal Quebec Canada

6. Department of Allergy and Clinical Immunology Centre Hospitalier Lyon‐Sud Pierre‐Bénite France

Abstract

AbstractWhile the early introduction of food allergens in the infant diet has been shown to be effective at preventing the development of food allergy (FA), its implementation in real life has been associated with various challenges. Interventions aimed at correcting skin barrier dysfunction have been explored in recent decades as a distinct or complementary mean to prevent allergic sensitization through the skin and subsequent development of FA. Studies assessing the application of emollient from birth have yielded conflicting results, and meta‐analyses have demonstrated either no effect or only a slight positive effect on FA prevention. However, a careful review of the clinical trials reveals that different emollients were used, which may have explained some of the discrepancies between study results. Emollient application protocols also varied widely between studies. While firm conclusions cannot be drawn with regard to their overall efficacy at preventing FA, the available data provide valuable insight into the characteristics that could be associated with a more effective intervention. Namely, successful trials tended to use emollients with an acidic pH of 5.5, applied over the entire body, and combined with topical corticosteroids in affected areas. Consensus on the optimal strategy to restore skin barrier function could help improve the homogeneity and clinical relevance of future trials on this topic. In the meantime, clinicians should avoid products associated with worse outcomes.

Publisher

Wiley

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Maternal influences on offspring food allergy;Immunological Reviews;2024-09-14

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