Affiliation:
1. Department of Pediatrics Kurashiki Central Hospital Kurashiki Okayama Japan
Abstract
AbstractIntroductionTherapeutic plasma exchange (TPE) is used for treating refractory Kawasaki disease (KD); however, there are few reports on its use in small children.MethodsNine children with refractory KD who underwent TPE between January 2010 and December 2022 were retrospectively investigated. Data on patient demographics, inflammatory markers, coronary artery lesions (CALs), TPE settings and complications, and outcomes were examined.ResultsA total of 37 TPE sessions were performed on nine patients, with 3–6 sessions per patient. The median body weight was 8.9 kg. C‐reactive protein, white blood cell (WBC), and interleukin‐6 levels significantly decreased (p < 0.05). Of the 33 coronary arteries with CALs before TPE, 44% and 3% had CALs at 1 month and 1 year after TPE, respectively. Minor complications, such as mild hypocalcemia and naturally recovering coagulopathy, occurred without serious complications.ConclusionsTPE for refractory KD may be safe and effective in preventing CALs.