Astrocytes in ischemic stroke: Crosstalk in central nervous system and therapeutic potential

Author:

Liu Jueling123ORCID,Guo Yuying124,Zhang Yunsha5,Zhao Xiaoxiao123,Fu Rong123,Hua Shengyu6,Xu Shixin124

Affiliation:

1. First Teaching Hospital of Tianjin University of Traditional Chinese Medicine Tianjin China

2. National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion First Teaching Hospital of Tianjin University of Traditional Chinese Medicine Tianjin China

3. Tianjin University of Traditional Chinese Medicine Tianjin China

4. Tianjin Key Laboratory of Translational Research of TCM Prescription and Syndrome Tianjin China

5. School of Integrative Medicine Tianjin University of Traditional Chinese Medicine Tianjin China

6. Institute of Traditional Chinese Medicine Tianjin University of Traditional Chinese Medicine Tianjin China

Abstract

In the central nervous system (CNS), a large group of glial cells called astrocytes play important roles in both physiological and disease conditions. Astrocytes participate in the formation of neurovascular units and interact closely with other cells of the CNS, such as microglia and neurons. Stroke is a global disease with high mortality and disability rate, most of which are ischemic stroke. Significant strides in understanding astrocytes have been made over the past few decades. Astrocytes respond strongly to ischemic stroke through a process known as activation or reactivity. Given the important role played by reactive astrocytes (RAs) in different spatial and temporal aspects of ischemic stroke, there is a growing interest in the potential therapeutic role of astrocytes. Currently, interventions targeting astrocytes, such as mediating astrocyte polarization, reducing edema, regulating glial scar formation, and reprogramming astrocytes, have been proven in modulating the progression of ischemic stroke. The aforementioned potential interventions on astrocytes and the crosstalk between astrocytes and other cells of the CNS will be summarized in this review.

Funder

National Natural Science Foundation of China

Publisher

Wiley

Subject

Neurology (clinical),General Medicine,Pathology and Forensic Medicine

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