Evaluation of levocetirizine in beagle dog and cynomolgus monkey telemetry assays: Defining the no QTc effect profile by timepoint and concentration‐QTc analysis
Author:
Affiliation:
1. Translational Safety & Bioanalytical Sciences, Amgen Research Thousand Oaks California USA
2. Amgen Clinical Pharmacology Modeling & Simulation Thousand Oaks California USA
3. Pharmacokinetics Amgen Research Thousand Oaks California USA
Publisher
Wiley
Subject
General Pharmacology, Toxicology and Pharmaceutics,General Biochemistry, Genetics and Molecular Biology,General Medicine,General Neuroscience
Link
https://onlinelibrary.wiley.com/doi/pdf/10.1111/cts.13454
Reference29 articles.
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3. Preclinical QT safety assessment: Cross-species comparisons and human translation from an industry consortium
4. Exposure-response analysis of drug-induced QT interval prolongation in telemetered monkeys for translational prediction to human
5. Can non-clinical repolarization assays predict the results of clinical thorough QT studies? Results from a research consortium
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