Development of everolimus, a novel oral mTOR inhibitor, across a spectrum of diseases

Author:

Lebwohl David1,Anak Özlem2,Sahmoud Tarek3,Klimovsky Judith1,Elmroth Ingrid2,Haas Tomas2,Posluszny Joseph3,Saletan Stephen3,Berg William3

Affiliation:

1. Novartis Pharmaceuticals Corporation; Florham Park New Jersey

2. Novartis Pharma AG; Basel Switzerland

3. Novartis Pharmaceuticals Corporation; East Hanover New Jersey

Publisher

Wiley

Subject

History and Philosophy of Science,General Biochemistry, Genetics and Molecular Biology,General Neuroscience

Reference75 articles.

1. Afinitor (everolimus tablets for oral administration) Afinitor Disperz (everolimus tablets for oral suspension) East Hanover, NJ Novartis Pharmaceuticals Corporation 2012

2. Isolation of a protein target of the FKBP12-rapamycin complex in mammalian cells;Sabers;J. Biol. Chem.,1995

3. Targeting tumorigenesis: development and use of mTOR inhibitors in cancer therapy;Yuan;J. Hematol. Oncol.,2009

4. Research and innovation in the development of everolimus for oncology;Lebwohl;Exp. Opin. Drug Discovery,2011

5. Targeting the mTOR signaling network for cancer therapy;Meric-Bernstam;J. Clin. Oncol.,2009

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