Dampened circadian amplitude of EEG power in women after menopause

Abstract

SummaryPostmenopausal women are at high risk of developing sleep–wake disturbances. We previously reported dampened circadian rhythms of melatonin, alertness and sleep in postmenopausal compared with young women. The present study aims to further explore electroencephalography power spectral changes in the sleep of postmenopausal women. Eight healthy postmenopausal women were compared with 12 healthy, naturally ovulating, young women in their mid‐follicular phase. Participants followed a regular 8‐hr sleep schedule for ≥ 2 weeks prior to laboratory entry. The laboratory visit included an 8‐hr baseline sleep period followed by an ultradian sleep–wake cycle procedure, consisting of alternating 1‐hr wake periods and nap opportunities. Electroencephalography power spectral analysis was performed on non‐rapid eye movement sleep obtained over a 48‐hr period. The baseline nocturnal sleep of postmenopausal women comprised lower power within delta and sigma, and higher power within alpha bands compared with that of younger women. During nighttime naps of the ultradian sleep–wake cycle procedure, lower power within delta and sigma, and higher power within beta bands were observed in postmenopausal women. During the ultradian sleep–wake cycle procedure, postmenopausal women presented lower power of delta, theta and sigma (14‐15 Hz), undetectable rhythms of delta and theta, and a dampened or undetectable rhythm of sigma (12‐15 Hz) power compared with younger women. Our results support the hypothesis of a dampened circadian variation of sleep microstructure in healthy‐sleeping postmenopausal women. Circadian changes with aging are potential mechanisms for increased susceptibility to develop sleep disturbances; however, further research is needed to clarify their clinical implications and contribution to insomnia.