Sophocarpine attenuates wear particle-induced implant loosening by inhibiting osteoclastogenesis and bone resorptionviasuppression of the NF-κB signalling pathway in a rat model

Author:

Zhou Chen-he123,Shi Zhong-li12,Meng Jia-hong12,Hu Bin12,Zhao Chen-chen12,Yang Yu-te12,Yu Wei12,Chen Ze-xin4,Heng Boon Chin5,Parkman Virginia-Jeni Akila3,Jiang Shuai6,Zhu Han-xiao12,Wu Hao-bo12,Shen Wei-liang12,Yan Shi-gui12ORCID

Affiliation:

1. Department of Orthopedic Surgery, Second Affiliated Hospital, School of Medicine; Zhejiang University; Hangzhou China

2. Orthopedic Research Institute of Zhejiang University; Hangzhou China

3. Department of Oral Medicine, Infection and Immunity; Harvard School of Dental Medicine; Boston MA USA

4. Center of Clinical Epidemiology & Biostatistics, Department of Science and Education, the Second Affiliated Hospital, School of Medicine; Zhejiang University; Hangzhou Zhejiang China

5. Faculty of Dentistry; The University of Hong Kong; Pokfulam Hong Kong

6. Department of Hand Surgery; The First Affiliated Hospital of Zhejiang University; Hangzhou China

Funder

National Natural Science Foundation of China

Publisher

Wiley

Subject

Pharmacology

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