Italian position paper (SIPMO‐SICMF) on medication‐related osteonecrosis of the jaw (MRONJ)

Author:

Bedogni Alberto12ORCID,Mauceri Rodolfo34ORCID,Fusco Vittorio5,Bertoldo Francesco6,Bettini Giordana12,Di Fede Olga3,Lo Casto Antonio7,Marchetti Claudio8,Panzarella Vera3ORCID,Saia Giorgia2,Vescovi Paolo9,Campisi Giuseppina34ORCID

Affiliation:

1. Regional Center for Prevention, Diagnosis and Treatment of Medication and Radiation‐Related Bone Diseases of the Head and Neck University of Padua, Padua (PD) Italy

2. Department of Neuroscience University of Padova Padua (PD) Italy

3. Department of Surgical, Oncological and Oral Sciences (Di.Chir.On.S.) University of Palermo Palermo (PA) Italy

4. Unit of Oral Medicine and Dentistry for frail patients, Department of Rehabilitation, fragility, and continuity of care, Regional Center for Research and Care of MRONJ University Hospital Palermo Palermo (PA) Italy

5. Oncology Unit, Azienda Ospedaliera di Alessandria SS, Antonio e Biagio e Cesare Arrigo Alessandria (AL) Italy

6. Department of Medicine University of Verona Verona (VR) Italy

7. Department of Biomedicine, Neuroscience and Advanced Diagnostic University of Palermo Palermo (PA) Italy

8. Department of Biomedical and Neuromotor Sciences University of Bologna Bologna (BO) Italy

9. Department of Medicine and Surgery, Oral Medicine and Laser Surgery Unit University Center of Dentistry, University of Parma Parma (PR) Italy

Abstract

AbstractObjectiveThis paper aims to describe the 2023 update position paper on MRONJ developed by the Italian Societies of Oral Pathology and Medicine (SIPMO) and of Maxillofacial Surgery (SICMF).MethodsThis is the second update following the 2013 and 2020 Italian position papers by the Expert panel, which is a representation of the two scientific societies (SIPMO and SICMF).The paper is based on an extensive analysis of the available literature from January 2003 to February 2020, and the subsequent review of literature conducted between March 2020 and December 2022 to include all new relevant published papers to confirm or modify the previous set of recommendations.ResultsThis position paper highlights the main issues of MRONJ on risk estimates, disease definition, diagnostic pathway, individual risk assessment, and the fundamental role of imaging in the diagnosis, classification, and management of MRONJ.ConclusionThe Expert Panel confirmed the MRONJ definition, the diagnostic work‐up, the clinical‐radiological staging system and the prophylactic drug holiday, as recognized by SIPMO‐SICMF; while, it presented novel indications regarding the categories at risk of MRONJ, the prevention strategies, and the treatment strategies associated with the therapeutic drug holiday.

Funder

Agenzia Italiana del Farmaco, Ministero della Salute

Publisher

Wiley

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