Repeated otilonium bromide administration prevents neurotransmitter changes in colon of rats underwent to wrap restraint stress

Author:

Traini Chiara1,Evangelista Stefano2,Girod Vincent3,Faussone-Pellegrini Maria Simonetta1,Vannucchi Maria Giuliana1

Affiliation:

1. Department of Experimental and Clinical Medicine; Research Unit of Histology and Embryology; Florence Italy

2. Ricerche SpA; Preclinical Development Dept.; Florence Italy

3. Syncrosome; Marseille France

Funder

Menarini I.F.R.

Publisher

Wiley

Subject

Cell Biology,Molecular Medicine

Reference41 articles.

1. Meta-analysis: the treatment of irritable bowel syndrome;Lesbros-Pantoflickova;Aliment Pharmacol Ther,2004

2. A distribution study with (14)C-otilonium bromide in the rat: evidence for selective tropism for large intestine after oral administration;Evangelista;Drug Metab Dispos,2000

3. Colonic smooth muscle cells and colonic motility patterns as a target for irritable bowel syndrome therapy: mechanisms of action of otilonium bromide;Rychter;Ther Adv Gastroenterol,2014

4. Effect of otilonium bromide and ibodutant on the internalization of the NK2 receptor in human colon;Cipriani;Neurogastroenterol Motil,2011

5. Randomized clinical trial: otilonium bromide improves frequency of abdominal pain, severity of distention and time to relapse in patients with irritable bowel syndrome;Clavé;Aliment Pharmacol Ther,2011

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