Taste and smell alterations affect nutritional status in children under chemotherapy

Author:

Grain Audrey12ORCID,Camuset Margaux1,Gras‐Leguen Christèle3,Hardouin Jean‐Benoit45,Scherdel Pauline3,Caldari Dominique1

Affiliation:

1. Paediatric Haematology and Oncology Department CHU of Nantes Nantes France

2. Inserm UMR 1307, CNRS UMR 6075 CRCINA2 Nantes Université Angers France

3. CIC FEA CHU of Nantes Nantes France

4. INSERM UMR 1246‐SPHERE Nantes Université Nantes France

5. Public Health Department CHU of Nantes Nantes France

Abstract

AbstractAimThis study aimed to evaluate the incidence of self‐reported taste and smell alterations (TSA) in cancer paediatric patients and evaluate the impact of TSA on nutritional status in this population. We also developed and validated a composite score to detect TSA in children undergoing chemotherapy.MethodsPaediatric patients who were undergoing chemotherapy in a paediatric oncology unit were included. TSA were assessed from the Gustonco questionnaire from which a composite score was developed and internally validated, eating behaviour was assessed using Child Eating Behaviour Questionnaire, and major weight loss was defined from nutritional status. All data were calculated at 1, 3 and 6 months after chemotherapy start. Associations between nutritional status and scores were studied by using logistic models.ResultsAmong 49 patients included, TSA occurred in 71.7% of patients at 1 month after chemotherapy start and persisted at 3 and 6 months. TSA led to altered appetite since 1 month after chemotherapy start. The occurrence of a major weight loss at 6 months seemed to be associated with a high Gustonco score.ConclusionTaste and smell alterations often occurred in paediatric cancer patients after chemotherapy start and seemed to be associated with impaired nutrition at 6 months after chemotherapy.

Funder

Ligue Contre le Cancer

Publisher

Wiley

Subject

General Medicine,Pediatrics, Perinatology and Child Health

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