Clinicopathological features, treatment modalities, and prognosis of esophageal neuroendocrine carcinoma: A single‐center retrospective study

Author:

Zhang Yao12ORCID,Liao Jiao Tao12,Lin Ying12,Liu Chang12,Wu Zhen Hua12,Yu Bo12,Sun Si12,Yu Hui12,Hui Xiao Hua12,Wu Xiang Hua12,Zhao Xin Min12,Wang Hui Jie12,Zheng Qiang34,Li Yuan34,Hu Zhi Huang12,Wang Jia Lei12

Affiliation:

1. Department of Thoracic Medical Oncology Fudan University Shanghai Cancer Center Shanghai China

2. Department of Thoracic Oncology, Shanghai Medical College Fudan University Shanghai China

3. Department of Pathology Fudan University Shanghai Cancer Center Shanghai China

4. Department of Oncology, Shanghai Medical College Fudan University Shanghai China

Abstract

ObjectivesEsophageal neuroendocrine carcinoma (ENEC) is a rare cancer that is highly malignant and related to a poor prognosis. In this retrospective study we aimed to elucidate the clinical characteristics, diagnosis and management of patients with ENEC and to evaluate the potential prognostic factors.MethodsAltogether 82 patients diagnosed with ENEC between January 2009 and December 2020 at the Fudan University Shanghai Cancer Center were retrospectively enrolled. Patients’ survival was analyzed using the Kaplan–Meier and log‐rank methods. Univariate and multivariate analyses and a Cox regression model were used to identify the prognostic factors.ResultsThe median overall survival (mOS) was 13 months in all patients. Multivariate analysis revealed that advanced tumor stage (hazard ratio [HR] 2.67, 95% confidence interval [CI] 1.07–6.66, P = 0.0353), liver (HR 3.36, 95% CI 1.53–7.41, P = 0.0026) and lung metastasis (HR 3.37, 95% CI 1.20–9.51, P = 0.0214) were associated with a poor prognosis. While positive chromogranin A (CgA) expression was related to a favorable outcome (HR 0.21, 95% CI 0.09–0.49, P < 0.001). Also, patients had adjustment of chemotherapy (dose reduction or less than three cycles) were prone to a worse prognosis compared with those did not (HR 4.36, 95% CI 2.10–9.08, P < 0.001).ConclusionIn patients with ENEC, advanced cancer stage, adjustment of chemotherapy, liver and lung metastasis were associated with a poor survival, while CgA expression was related to a favorable prognosis.

Publisher

Wiley

Subject

Gastroenterology

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