Unlike dietary restriction, rapamycin fails to extend lifespan and reduce transcription stress in progeroid DNA repair‐deficient mice

Author:

Birkisdóttir María B.1ORCID,Jaarsma Dick2ORCID,Brandt Renata M. C.3,Barnhoorn Sander3,Vliet Nicole3,Imholz Sandra4,Oostrom Conny T.4,Nagarajah Bhawani4,Portilla Fernández Eliana5ORCID,Roks Anton J. M.5ORCID,Elgersma Ype2ORCID,Steeg Harry4ORCID,Ferreira José A.6,Pennings Jeroen L. A.4ORCID,Hoeijmakers Jan H. J.137ORCID,Vermeij Wilbert P.1ORCID,Dollé Martijn E. T.4ORCID

Affiliation:

1. Princess Máxima Center for Pediatric Oncology, Genome Instability and Nutrition ONCODE Institute Utrecht The Netherlands

2. Department of Neuroscience Erasmus MC Rotterdam The Netherlands

3. Department of Molecular Genetics Erasmus MC Rotterdam The Netherlands

4. Centre for Health Protection National Institute for Public Health and the Environment (RIVM Bilthoven The Netherlands

5. Division of Vascular Medicine and Pharmacology Department of Internal Medicine Erasmus MC Rotterdam The Netherlands

6. Department of Statistics, Informatics and Modelling National Institute for Public Health and the Environment (RIVM Bilthoven The Netherlands

7. CECAD Forschungszentrum Köln Germany

Funder

National Institute on Aging

Deutsche Forschungsgemeinschaft

Rijksinstituut voor Volksgezondheid en Milieu

Publisher

Wiley

Subject

Cell Biology,Ageing

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