Predictive accuracy of the ASIG algorithm in a prospective systemic sclerosis cohort undergoing annual screening for pulmonary arterial hypertension

Author:

Brown Zoe12ORCID,Morrisroe Kathleen12,Hansen Dylan2,Stevens Wendy2,Proudman Susanna34,Teng Gim G.5,Low Andrea67,Nikpour Mandana12

Affiliation:

1. Department of Medicine The University of Melbourne at St Vincent's Hospital Melbourne Victoria Australia

2. Department of Rheumatology St Vincent's Hospital (Melbourne) Melbourne Victoria Australia

3. Rheumatology Unit Royal Adelaide Hospital Adelaide South Australia Australia

4. Discipline of Medicine University of Adelaide Adelaide South Australia Australia

5. Department of Medicine, Division of Rheumatology Alexandra Hospital, National University Health System Singapore

6. Department of Rheumatology and Immunology Singapore General Hospital Singapore

7. Duke National University of Singapore Singapore

Abstract

AbstractThe Australian Scleroderma Interest Group (ASIG) algorithm for screening pulmonary arterial hypertension (PAH) in systemic sclerosis (SSc) requires only respiratory function tests and serum N‐terminal pro‐brain natriuretic peptide as first‐tier tests, and is recommended in international guidelines. In this communication, we present the findings of the application of the ASIG screening algorithm to a Singaporean cohort undergoing prospective annual screening for PAH, which shows a high negative predictive value. The ASIG algorithm may offer an alternative to more complex and costly SSc‐PAH screening algorithms.

Publisher

Wiley

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