Pharmacokinetics of idarucizumab and its target dabigatran in patients requiring urgent reversal of the anticoagulant effect of dabigatran
Author:
Affiliation:
1. Boehringer Ingelheim Pharma GmbH and Co. KG Biberach an der Riss Germany
2. Boehringer Ingelheim Pharmaceuticals, Inc Ridgefield Connecticut
3. Thomas Jefferson University Philadelphia Pennsylvania
Funder
Boehringer Ingelheim
Publisher
Wiley
Subject
Hematology
Link
https://onlinelibrary.wiley.com/doi/pdf/10.1111/jth.14476
Reference12 articles.
1. Current knowledge on assessing the effects of and managing bleeding and urgent procedures with direct oral anticoagulants
2. 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS
3. When and how to use antidotes for the reversal of direct oral anticoagulants: guidance from the SSC of the ISTH
4. European Medicines Agency.Praxbind [idarucizumab] product information.http://wwwemaeuropaeu/docs/en_GB/document_library/EPAR_-_Product_Information/human/003986/WC500197462pdf[Internet].2018. Available fromhttp://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Product_Information/human/003986/WC500197462.pdf
5. Design and rationale for RE-VERSE AD: A phase 3 study of idarucizumab, a specific reversal agent for dabigatran
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