Prevalence and clinical profile of comorbid anxiety in young adult patients with first‐episode and drug‐naive major depressive disorder

Author:

Luo Rui‐Chen‐Xi1,Wang Dongmei23,Zhou Huixia23,Lang Xiao E4,Zhang Xiang‐Yang123ORCID

Affiliation:

1. Department of Psychiatry School of Mental Health and Psychological Sciences, Anhui Medical University Hefei China

2. CAS Key Laboratory of Mental Health Institute of Psychology, Chinese Academy of Sciences Beijing China

3. Department of Psychology University of Chinese Academy of Sciences Beijing China

4. Department of Psychiatry First Hospital of Shanxi Medical University Taiyuan China

Abstract

AbstractAimPatients with major depressive disorder (MDD) frequently have coexisting anxiety disorders. However, few studies have focused on the prevalence and risk factors of comorbid anxiety symptoms in young adult first‐episode and drug‐naive (FEDN) MDD patients.MethodsWe recruited 520 FEDN MDD patients and collected their demographic and clinical data. The Hamilton Depression Rating Scale (HAMD), the Hamilton Anxiety Rating Scale (HAMA) and the positive scale of the Positive and Negative Syndrome Scale (PANSS) were used to measure depressive symptoms, anxiety symptoms and psychotic symptoms, respectively.ResultsAnxiety symptoms were found in 79.6% of young adult patients. Besides, anxiety group patients had a higher prevalence of psychotic symptoms than the non‐anxiety group. Anxiety symptoms were substantially related to suicide attempts in young adult patients. Logistic analysis shows that suicide attempts and total HAMD scores were significantly associated with anxiety symptoms.ConclusionsThe findings show that anxiety symptoms are common in Chinese young adult MDD patients. The anxiety group was more likely to have psychotic symptoms, suicide attempts, and more severe depressive symptoms than the non‐anxiety group. Suicide attempts were associated with anxiety symptoms in young adult MDD patients, suggesting the importance of reducing anxiety symptoms in this population to prevent suicides.

Funder

Wu Jieping Medical Foundation

Publisher

Wiley

Subject

Biological Psychiatry,Psychiatry and Mental health,Pshychiatric Mental Health

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