HIV DNA reservoir and elevated PD‐1 expression of CD4 T‐cell subsets particularly persist in the terminal ileum of HIV‐positive patients despite cART-Reference-Cited by-同舟云学术

HIV DNA reservoir and elevated PD‐1 expression of CD4 T‐cell subsets particularly persist in the terminal ileum of HIV‐positive patients despite cART

Published:2021-01-09 Issue:5 Volume:22 Page:397-408
ISSN:1464-2662
Container-title:HIV Medicine
language:en
Short-container-title:HIV Med

Author:

Horn C¹²³^ORCID,Augustin M¹²³,Ercanoglu MS²⁴,Heger E⁴,Knops E⁴,Bondet V⁵,Duffy D⁵,Chon S‐H⁶^ORCID,Nierhoff D⁷,Oette M⁸,Schäfer H⁸,Vivaldi C⁸,Held K⁹¹⁰,Anderson J⁹,Geldmacher C⁹¹⁰,Suárez I¹,Rybniker J¹²³,Klein F³⁴,Fätkenheuer G¹³,Müller‐Trutwin M¹¹,Lehmann C¹²³

Affiliation:

1. Division of Infectious Diseases Department I of Internal Medicine University of Cologne Cologne Germany

2. Center for Molecular Medicine Cologne (CMMC) University of Cologne Cologne Germany

3. German Center for Infection Research (DZIF) Cologne Germany

4. Institute of Virology Faculty of Medicine and University Hospital of Cologne University of Cologne Cologne Germany

5. Immunobiology of Dendritic Cells Unit Inserm U1223 Institut Pasteur Paris Cedex 15 France

6. Department of General, Visceral Surgery and Cancer Surgery University Hospital Cologne Cologne Germany

7. Clinic for Gastroenterology and Hepatology University Hospital of Cologne Cologne Germany

8. Clinic for Coloproctology PanKlinik, Cologne Germany

9. Division of Infectious Diseases and Tropical Medicine University HospitalLMU Munich Munich Germany

10. German Center for Infection Research (DZIF) Munich Germany

11. Unité HIV Inflammation & Persistence Institut Pasteur Paris Cedex 15 France

Funder

Deutsches Zentrum für Infektionsforschung

Publisher

Wiley

Subject

Pharmacology (medical),Infectious Diseases,Health Policy

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/hiv.13031

Reference47 articles.

1. Latent infection of CD4+ T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy

2. HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation

3. HIV persistence in the setting of antiretroviral therapy: when, where and how does HIV hide?

4. Persistence of HIV in Gut‐Associated Lymphoid Tissue despite Long‐Term Antiretroviral Therapy

5. Site-Specific Differences in T Cell Frequencies and Phenotypes in the Blood and Gut of HIV-Uninfected and ART-Treated HIV+ Adults

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