Autophagy compensates impaired energy metabolism in CLPXP-deficient Podospora anserina strains and extends healthspan
Author:
Affiliation:
1. Institute of Molecular Biosciences and Cluster of Excellence ‘Macromolecular Complexes’; Department of Biosciences; J. W. Goethe University; Frankfurt Germany
Funder
Deutsche Forschungsgemeinschaft
Publisher
Wiley
Subject
Cell Biology,Aging
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1111/acel.12600/fullpdf
Reference36 articles.
1. ClpX stimulates the mitochondrial unfolded protein response (UPRmt) in mammalian cells;Al-Furoukh;Biochim. Biophys. Acta,2015
2. Copper-modulated gene expression and senescence in the filamentous fungus Podospora anserina;Borghouts;Mol. Cell. Biol.,2001
3. Cyclophilin D links programmed cell death and organismal aging in Podospora anserina;Brust;Aging Cell,2010
4. Cyclophilin D is required for mitochondrial removal by autophagy in cardiac cells;Carreira;Autophagy,2010
5. Inhibition of the mitochondrial protease ClpP as a therapeutic strategy for human acute myeloid leukemia;Cole;Cancer Cell,2015
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