Sex, ethnicity, and slow acetylator profile are the major causes of hepatotoxicity induced by antituberculosis drugs

Author:

Chamorro Julián G1,Castagnino Jorge P2,Musella Rosa M2,Nogueras Mabel3,Aranda Federico M1,Frías Ana2,Visca Mabel2,Aidar Omar2,Perés Silvia1,de Larrañaga Gabriela F1

Affiliation:

1. Hemostasis and Thrombosis Laboratory; Hospital of Infectious Diseases “Dr. F. J. Muñiz”; Buenos Aires Argentina

2. Pneumotisiology Division; Hospital of Infectious Diseases “Dr. F. J. Muñiz”; Buenos Aires Argentina

3. Intensive Care Department of Critical Infected Patient (D.A.I.P.I.C.); Hospital of Infectious Diseases “Dr. F. J. Muñiz”; Buenos Aires Argentina

Funder

National Ministry of Health

Publisher

Wiley

Subject

Gastroenterology,Hepatology

Reference34 articles.

1. World Health Organization Global tuberculosis control: surveillance, planning, financing: WHO report 2006 2006

2. World Health Organization Actions for life towards a world free of tuberculosis: the global plan to stop TB 2006-2015 2006

3. Bossio JC Fernandez HR Arias SJ et al NOTIFICACIÓN DE CASOS DE TUBERCULOSIS EN LA REPUBLICA ARGENTINA PERÍODO 1980-2009 2010

4. NAT2 6A, a haplotype of the N-acetyltransferase 2 gene, is an important biomarker for risk of anti-tuberculosis drug-induced hepatotoxicity in Japanese patients with tuberculosis;Higuchi;World J. Gastroenterol.,2007

5. Genetic variations of NAT2 and CYP2E1 and isoniazid hepatotoxicity in a diverse population;Yamada;Pharmacogenomics,2009

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