Intracellular sorting and transcytosis of the rat transferrin receptor antibody OX26 across the blood-brain barrierin vitrois dependent on its binding affinity
Author:
Affiliation:
1. National Research Council of Canada; Human Health Therapeutics Research Centre; Ottawa ON Canada
2. Antibody Discovery and Protein Engineering; MedImmune, Milstein Building; Granta Park Cambridge UK
Funder
MedImmune
Publisher
Wiley
Subject
Cellular and Molecular Neuroscience,Biochemistry
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1111/jnc.14482/fullpdf
Reference35 articles.
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3. Transferrin receptor (TfR) trafficking determines brain uptake of TfR antibody affinity variants;Bien-Ly;J. Exp. Med.,2014
4. Trafficking of gold nanoparticles coated with the 8D3 anti-transferrin receptor antibody at the mouse blood-brain barrier;Cabezon;Mol. Pharm.,2015
5. Transferrin receptor gene is hyperexpressed and transcriptionally regulated in differentiating erythroid cells;Chan;J. Biol. Chem.,1992
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