<scp>ETS1</scp> phosphorylation at threonine 38 is associated with the cell of origin of diffuse large B cell lymphoma and sustains the growth of tumour cells-Reference-Cited by-同舟云学术

ETS1 phosphorylation at threonine 38 is associated with the cell of origin of diffuse large B cell lymphoma and sustains the growth of tumour cells

Published:2023-08-16 Issue:2 Volume:203 Page:244-254
ISSN:0007-1048
Container-title:British Journal of Haematology
language:en
Short-container-title:Br J Haematol

Author:

Chung Elaine Y. L.¹,Sartori Giulio¹,Ponzoni Maurilio²^ORCID,Cascione Luciano¹³,Priebe Valdemar¹,Xu‐Monette Zijun Y.⁴,Fang Xiaosheng⁴^ORCID,Zhang Mingzhi⁴,Visco Carlo⁵^ORCID,Tzankov Alexandar⁶,Rinaldi Andrea¹,Sgrignani Jacopo⁷,Zucca Emanuele⁸,Rossi Davide¹⁸,Cavalli Andrea⁷,Inghirami Giorgio⁹,Scott David W.¹⁰¹¹,Young Ken H.⁴,Bertoni Francesco¹⁸^ORCID

Affiliation:

1. Institute of Oncology Research, Faculty of Biomedical Sciences, USI Bellinzona Switzerland

2. IRCCS San Raffaele Hospital Scientific Institute, Vita Salute San Raffaele University Milan Italy

3. SIB Swiss Institute of Bioinformatics Lausanne Switzerland

4. Duke University Medical Center Durham North Carolina USA

5. Section of Hematology, Department of Medicine University of Verona Verona Italy

6. Pathology, Institute of Medical Genetics and Pathology University Hospital Basel Switzerland

7. Faculty of Biomedical Sciences, Institute for Research in Biomedicine, USI Bellinzona Switzerland

8. Oncology Institute of Southern Switzerland, Ente Ospedaliero Cantonale Bellinzona Switzerland

9. Pathology and Laboratory Medicine Department, Weill Cornell Medicine New York New York USA

10. Centre for Lymphoid Cancer, BC Cancer University of British Columbia Vancouver British Columbia Canada

11. Department of Medicine University of British Columbia Vancouver British Columbia Canada

Abstract

SummaryThe transcriptional factor ETS1 is upregulated in 25% of diffuse large B cell lymphoma (DLBCL). Here, we studied the role of ETS1 phosphorylation at threonine 38, a marker for ETS1 activation, in DLBCL cellular models and clinical specimens. p‐ETS1 was detected in activated B cell‐like DLBCL (ABC), not in germinal centre B‐cell‐like DLBCL (GCB) cell lines and, accordingly, it was more common in ABC than GCB DLBCL diagnostic biopsies. MEK inhibition decreased both baseline and IgM stimulation‐induced p‐ETS1 levels. Genetic inhibition of phosphorylation of ETS1 at threonine 38 affected the growth and the BCR‐mediated transcriptome program in DLBCL cell lines. Our data demonstrate that ETS1 phosphorylation at threonine 38 is important for the growth of DLBCL cells and its pharmacological inhibition could benefit lymphoma patients.

Funder

Rotary Foundation

Swiss Cancer Research Foundation

Publisher

Wiley

Subject

Hematology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/bjh.19018

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