Functional efficacy of adenosine A2A receptor agonists is positively correlated to their receptor residence time
Author:
Publisher
Wiley
Subject
Pharmacology
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1111/j.1476-5381.2012.01897.x/fullpdf
Reference47 articles.
1. (-)-S-[3H]CGP-12177 and its use to determine the rate constants of unlabeled beta-adrenergic antagonists;Affolter;Proc Natl Acad Sci USA,1985
2. Integrated methods for the construction of three dimensional models and computational probing of structure-function relations in G-protein coupled receptors;Ballesteros;Methods Neurosci,1995
3. New, non-adenosine, high-potency agonists for the human adenosine A2B receptor with an improved selectivity profile compared to the reference agonist N-ethylcarboxamidoadenosine;Beukers;J Med Chem,2004
4. Operational models of pharmacological agonism;Black;Proc R Soc Lond B Biol Sci,1983
5. Binding thermodynamics at A1 and A2A adenosine receptors;Borea;Life Sci,1996
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