Nanobodies against surface biomarkers enable the analysis of tumor genetic heterogeneity in uveal melanoma patient-derived xenografts

Author:

Crépin Ronan1,Gentien David2,Duché Angeline2,Rapinat Audrey2,Reyes Cecile2,Némati Fariba2,Massonnet Gérald2,Decaudin Didier23,Djender Selma14,Moutel Sandrine245,Desrumeaux Klervi1,Cassoux Nathalie6,Piperno-Neumann Sophie7,Amigorena Sebastian48910,Perez Franck145,Roman-Roman Sergio2,de Marco Ario191011ORCID

Affiliation:

1. Tumor Target and Therapeutic Antibody - Identification Platform (TAb-IP); Paris Cedex 05 France

2. Translational Research Department; Institut Curie; PSL Research University; Paris France

3. Medical Oncology Department; Institut Curie; Paris Cedex 05 France

4. Institut Curie; PSL Research University; Paris Cedex 05 France

5. UMR144; Institut Curie; Paris France

6. Department of Surgical Oncology; Institut Curie; Paris France

7. Department of Medical Oncology; Institut Curie; Paris France

8. INSERM Unit 932; Paris cedex 05 France

9. SIRIC INCa-DGOS-4654; Paris France

10. CIC IGR Curie 1428; Paris France

11. Department of Biomedical Sciences and Engineering; University of Nova Gorica (UNG); Vipava Slovenia

Funder

Centre National de la Recherche Scientifique

Institut National de la Santé et de la Recherche Médicale

Institut Curie

COPIO/ITMO-TS/Aviesan

Région île de France

Labex DCBIOL

Publisher

Wiley

Subject

Dermatology,General Biochemistry, Genetics and Molecular Biology,Oncology

Reference53 articles.

1. The availability of a recombinant anti-SNAP antibody in VHH format amplifies the application flexibility of SNAP-tagged proteins;Aliprandi;J. Biomed. Biotechnol.,2010

2. Establishment of novel cell lines recapitulating the genetic landscape of uveal melanoma and preclinical validation of mTOR as a therapeutic target;Amirouchene-Angelozzi;Mol. Oncol.,2014

3. In-depth proteomic profiling of the uveal melanoma secretome;Angi;Oncotarget,2016

4. Detection of circulating melanoma cells in choroidal melanocytic lesions;Bande;BMC Res. Notes,2015

5. Possible implications of MCAM expression in metastasis and non-metastatic of primary uveal melanoma patients;Beutel;Curr. Eye Res.,2009

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