Receptor homodimerization plays a critical role in a novel dominant negativeP2RY12variant identified in a family with severe bleeding-Reference-Cited by-同舟云学术

Receptor homodimerization plays a critical role in a novel dominant negativeP2RY12variant identified in a family with severe bleeding

Published:2017-12-02 Issue:1 Volume:16 Page:44-53
ISSN:1538-7933
Container-title:Journal of Thrombosis and Haemostasis
language:en
Short-container-title:J Thromb Haemost

Author:

Mundell S. J.¹,Rabbolini D.²³,Gabrielli S.²³,Chen Q.²³,Aungraheeta R.¹,Hutchinson J. L.¹,Kilo T.⁴,Mackay J.⁵,Ward C. M.²³,Stevenson W.²³,Morel-Kopp M.-C.²³

Affiliation:

1. School of Physiology, Pharmacology and Neuroscience; University of Bristol; Bristol UK

2. Department of Haematology and Transfusion Medicine; Royal North Shore Hospital; Sydney Australia

3. Northern Blood Research Centre; Kolling Institute; The University of Sydney; Sydney Australia

4. Haematology Department; Westmead Children's Hospital; Sydney Australia

5. School of Molecular Biosciences; The University of Sydney; Sydney Australia

Funder

British Heart Foundation

Publisher

Wiley

Subject

Hematology

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1111/jth.13900/fullpdf

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2. Molecular bases of defective signal transduction in the platelet P2Y12 receptor of a patient with congenital bleeding;Cattaneo;Proc Natl Acad Sci USA,2003

3. Rare platelet GPCR variants: what can we learn?;Nisar;Br J Pharmacol,2015

4. Inherited dysfunctional platelet P2Y12 receptor mutations associated with bleeding disorders;Lecchi;Hamostaseologie,2016

5. Novel molecular defect in the platelet ADP receptor P2Y12 of a patient with haemorrhagic diathesis;Remijn;Clin Chem Lab Med,2007

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