Term‐born infants with a perinatal stroke frequently had seizures and were prescribed anti‐seizure medication at discharge

Author:

Barsch Bergqvist Alice1ORCID,Simatou Eleni23,Skiöld Beatrice4,Mitha Ayoub35,Bolk Jenny136ORCID

Affiliation:

1. Sachs' Children and Youth Hospital, Södersjukhuset Stockholm Sweden

2. Department of Child Neurology, Astrid Lindgren Children's Hospital, Karolinska University Hospital Stockholm Sweden

3. Division of Clinical Epidemiology, Department of Medicine Solna Karolinska Institutet Stockholm Sweden

4. Department of Women's and Children's Health Karolinska Institutet Stockholm Sweden

5. CHU Lille, Paediatric and Neonatal Intensive Care Transport Unit, Department of Emergency Medicine, SAMU 59 Lille University Hospital Lille France

6. Department of Clinical Science and Education Södersjukhuset Karolinska Institutet Stockholm Sweden

Abstract

AbstractAimWe investigated the prevalence of seizures in term‐born infants with a perinatal stroke in Swedish neonatal wards, assessed the anti‐seizure medication prescribed and determined the accuracy of diagnostic codes.MethodsThis cross‐sectional study used data from the Swedish Neonatal Quality Register. The cases were infants born at ≥37 weeks in 2009–2018 and admitted to a neonatal ward in Stockholm County with a stroke diagnosis, confirmed by their medical chart. The controls were all Swedish infants born during those years.ResultsThere were 76 infants with a confirmed perinatal stroke: 51 ischaemic and 25 haemorrhagic. Seizures were documented in 66/76 (87%) of infants with a stroke and 0.2% of the controls. Anti‐seizure medication was administered to 64/66 (97%) infants with a stroke and seizures. In 60 cases, the drugs administered were specified, with phenobarbital used in 59/60 cases (98%). More than one drug was administered to 25/60 (42%) infants and 31/60 (52%) were discharged with anti‐seizure medication. The positive predictive value for the stroke diagnostic codes was 80.5% (95% CI 76.5–84.5).ConclusionSeizures were common in infants with a perinatal stroke. More than one anti‐seizure drug was often required and many infants were on anti‐seizure medication at discharge, against Swedish recommendations.

Funder

H.K.H. Kronprinsessan Lovisas Förening för Barnasjukvård

Linnéa och Josef Carlssons Stiftelse

Petrus och Augusta Hedlunds Stiftelse

Stiftelsen Samariten

Stiftelsen Sven Jerrings Fond

Publisher

Wiley

Subject

General Medicine,Pediatrics, Perinatology and Child Health

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