Pig-to-baboon liver xenoperfusion utilizing GalTKO.hCD46 pigs and glycoprotein Ib blockade
Author:
Affiliation:
1. Department of Surgery; University of Maryland School of Medicine; Baltimore MD USA
2. Laboratory for Thrombosis Research; IRC; KU Leuven Kulak; Kortrijk Belgium
3. Revivicor, Inc.; Blacksburg VA USA
Publisher
Wiley
Subject
Transplantation,Immunology
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1111/xen.12093/fullpdf
Reference28 articles.
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2. Extracorporeal liver perfusion as hepatic assist in acute liver failure: a review of world experience;Pascher;Xenotransplantation,2002
3. Activation of human platelets by the membrane-expressed A1 domain of von Willebrand factor;Schulte am Esch;Blood,1997
4. Disordered regulation of coagulation and platelet activation in xenotransplantation;Robson;Xenotransplantation,2000
5. The vascular and coagulation issues in xenotransplantation;Cowan;Curr Opin Organ Transplant,2009
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1. Expression of human thrombomodulin by GalTKO.hCD46 pigs modulates coagulation cascade activation by endothelial cells and during ex vivo lung perfusion with human blood;Xenotransplantation;2023-09-28
2. A bioartificial transgenic porcine whole liver expressing human proteins alleviates acute liver failure in pigs;Hepatobiliary & Pancreatic Diseases International;2022-06
3. Current Barriers to Clinical Liver Xenotransplantation;Frontiers in Immunology;2022-02-23
4. hEPCR.hTBM.hCD47.hHO‐1 with donor clodronate and DDAVP treatment improves perfusion and function of GalTKO.hCD46 porcine livers perfused with human blood;Xenotransplantation;2022-02-15
5. Humanized von Willebrand factor reduces platelet sequestration in ex vivo and in vivo xenotransplant models;Xenotransplantation;2021-10-17
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