Bioassay-Guided Isolation and Structural Modification of the Anti-TB Resorcinols fromArdisia gigantifolia

Author:

Guan Yi-Fu12,Song Xun13,Qiu Ming-Hua4,Luo Shi-Hong4,Wang Bao-Jie5,Van Hung Nguyen6,Cuong Nguyen M.7,Soejarto Djaja Doel8,Fong Harry H.S.8,Franzblau Scott G.5,Li Sheng-Hong4,He Zhen-Dan3,Zhang Hong-Jie1

Affiliation:

1. School of Chinese Medicine; Hong Kong Baptist University; Hong Kong SAR China

2. HKBU Institute of Research and Continuing Education; Shenzhen 518057 China

3. Department of Pharmacy; School of Medicine; Key Laboratory of Novel Health Care Products; Engineering Laboratory of Shenzhen Natural small molecule Innovative Drugs; Shenzhen University; Shenzhen 518060 China

4. State Key Laboratory of Phytochemistry and Plant Resources in West China; Kunming Institute of Botany; Chinese Academy of Sciences; Kunming 650201 Yunnan China

5. Institute for Tuberculosis Research; College of Pharmacy; University of Illinois at Chicago; 833 South Wood Street Chicago IL 60612 USA

6. Institute of Marine Biochemistry of the Vietnam Academy of Science and Technology (VAST); 18 Hoang Quoc Viet Road, Cau Giay Hanoi Vietnam

7. Cuc Phuong National Park; Nho Quan District Ninh Binh Province Vietnam

8. Department of Medicinal Chemistry and Pharmacognosy; College of Pharmacy; University of Illinois at Chicago; 833 South Wood Street Chicago IL 60612 USA

Funder

Hong Kong Baptist University

National Natural Science Foundation of China

National Institutes of Health

Foreign Agricultural Service of the USDA

Shenzhen strategic emerging industry development project

Publisher

Wiley

Subject

Molecular Medicine,Biochemistry,Drug Discovery,Pharmacology,Organic Chemistry

Reference18 articles.

1. The resumption of consumption - a review on tuberculosis;Ducati;Mem Inst Oswaldo Cruz,2006

2. Rifampicin and rifapentine significantly reduce concentrations of bedaquiline, a new anti-TB drug;Svensson;J Antimicrob Chemother,2015

3. Natural products to drugs: natural product derived compounds in clinical trials;Butler;Nat Prod Rep,2005

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