LUF7244, an allosteric modulator/activator of K v 11.1 channels, counteracts dofetilide‐induced torsades de pointes arrhythmia in the chronic atrioventricular block dog model-Reference-Cited by-同舟云学术

LUF7244, an allosteric modulator/activator of K v 11.1 channels, counteracts dofetilide‐induced torsades de pointes arrhythmia in the chronic atrioventricular block dog model

Published:2019-08-30 Issue:19 Volume:176 Page:3871-3885
ISSN:0007-1188
Container-title:British Journal of Pharmacology
language:en
Short-container-title:Br J Pharmacol

Author:

Qile Muge¹,Beekman Henriette D.M.¹,Sprenkeler David J.¹,Houtman Marien J.C.¹,Ham Willem B.¹²,Stary‐Weinzinger Anna²,Beyl Stanislav²,Hering Steffen²,Berg Dirk‐Jan³,Lange Elizabeth C.M.³,Heitman Laura H.⁴,IJzerman Ad P.⁴,Vos Marc A.¹,Heyden Marcel A.G.¹^ORCID

Affiliation:

1. Department of Medical PhysiologyUniversity Medical Centre Utrecht Utrecht The Netherlands

2. Department of Pharmacology and ToxicologyUniversity of Vienna Vienna Austria

3. Division of Systems Biomedicine and Pharmacology, Leiden Academic Centre for Drug ResearchLeiden University Leiden The Netherlands

4. Division of Drug Discovery and Safety, Leiden Academic Centre for Drug ResearchLeiden University Leiden The Netherlands

Funder

Austrian Science Fund

Publisher

Wiley

Subject

Pharmacology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/bph.14798

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4. Dehydroevodiamine and hortiamine, alkaloids from the traditional Chinese herbal drug Evodia rutaecarpa, are IKr blockers with proarrhythmic effects in vitro and in vivo

5. Selective late sodium current inhibitor GS-458967 suppresses Torsades de Pointes by mostly affecting perpetuation but not initiation of the arrhythmia

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