Application of a patient‐centered reverse translational systems‐based approach to understand mechanisms of an adverse drug reaction of immune checkpoint inhibitors

Author:

Kim Sarah1ORCID,Lahu Gezim2,Vakilynejad Majid3,Soldatos Theodoros G.4,Jackson David B.4,Lesko Lawrence J.1,Trame Mirjam N.1

Affiliation:

1. Center for Pharmacometrics and Systems Pharmacology Department of Pharmaceutics College of Pharmacy University of Florida Orlando Florida USA

2. thinkQ2 Baar Switzerland

3. Takeda Oncology Cambridge Massachusetts USA

4. Molecular Health GmbH Heidelberg Germany

Publisher

Wiley

Subject

General Pharmacology, Toxicology and Pharmaceutics,General Biochemistry, Genetics and Molecular Biology,General Medicine,General Neuroscience

Reference47 articles.

1. YERVOY (ipilimumab) injection label from FDA website.U.S. Food and Drug Administration 2018.https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/125377s094lbl.pdf.

2. OPDIVO (nivolumab) label from FDA website.U.S. Food and Drug Administration 2019.https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/125554s070lbl.pdf.

3. KEYTRUDA (pembrolizumab) label from FDA website.U.S. Food and Drug Administration 2019.https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/125514s040lbl.pdf.

4. Immunotherapy and Novel Combinations in Oncology: Current Landscape, Challenges, and Opportunities

5. Challenges and Opportunities for Quantitative Clinical Pharmacology in Cancer Immunotherapy: Something Old, Something New, Something Borrowed, and Something Blue

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