Backtracking childhood leukaemia to birth: A battle of addition-Reference-Cited by-同舟云学术

Backtracking childhood leukaemia to birth: A battle of addition

Published:2024-09-05 Issue: Volume: Page:
ISSN:0007-1048
Container-title:British Journal of Haematology
language:en
Short-container-title:Br J Haematol

Author:

Spector Logan G.¹^ORCID,de Smith Adam J.²^ORCID

Affiliation:

1. Division of Epidemiology and Clinical Research, Department of Pediatrics University of Minnesota Medical School Minneapolis Minnesota USA

2. Center for Genetic Epidemiology, Department of Population and Public Health Sciences University of Southern California Keck School of Medicine, USC Norris Comprehensive Cancer Center Los Angeles California USA

Abstract

Paediatric leukaemia has a long tail of driver mutations each of which must be ‘backtracked’ to samples taken at birth to identify the prenatal origin of a subtype. Presently, Bardini et al. describe the first successful backtracking of an NUTM1 rearrangement, which sheds light on the biology of this particular alteration. Continued backtracking of NUTM1 rearrangements, and all leukaemia‐typical somatic alterations, is necessary to fully understand the prenatal origin of these diseases.Commentary on: Bardini et al. Prenatal origin of NUTM1 gene rearrangement in infant B‐cell precursor acute lymphoblastic leukaemia. Br J Haematol 2024 (Online ahead of print). doi: 10.1111/bjh.19685.

Publisher

Wiley

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/bjh.19747

Reference11 articles.

1. Favorable outcome of NUTM1-rearranged infant and pediatric B cell precursor acute lymphoblastic leukemia in a collaborative international study

2. NUTM1 is a recurrent fusion gene partner in B-cell precursor acute lymphoblastic leukemia associated with increased expression of genes on chromosome band 10p12.31-12.2

3. The Prenatal Origin of Childhood Leukemia: Potential Applications for Epidemiology and Newborn Screening

4. Backtracking NOM1::ETV6 fusion to neonatal pathogenesis of t(7;12) (q36;p13) infant AML

5. Covert pre-leukaemic clones in healthy co-twins of patients with childhood acute lymphoblastic leukaemia