Radiotherapy and prognostic factors in adnexal carcinomas: A retrospective study of 657 patients from the French <scp>CARADERM</scp> network-Reference-Cited by-同舟云学术

Radiotherapy and prognostic factors in adnexal carcinomas: A retrospective study of 657 patients from the French CARADERM network

Published:2024-06-12 Issue: Volume: Page:
ISSN:0926-9959
Container-title:Journal of the European Academy of Dermatology and Venereology
language:en
Short-container-title:Acad Dermatol Venereol

Author:

Zagala Robin¹²^ORCID,Dalle Stephane³⁴^ORCID,Beylot‐Barry Marie²⁵^ORCID,Meyer Nicolas⁶^ORCID,Saiag Philippe⁷⁸^ORCID,Kramkimel Nora⁹,Lebbe Celeste¹⁰¹¹^ORCID,Zehou Ouidad¹²^ORCID,Amini‐Adle Mona¹³,Grob Jean‐Jacques¹⁴^ORCID,Arnault Jean‐Philippe¹⁵,Maubec Eve¹⁶¹⁷^ORCID,Granel‐Brocard Florence¹⁸,Cribier Bernard¹⁹^ORCID,Quereux Gaelle²⁰,Brunet‐Possenti Florence²¹^ORCID,Dalac Sophie²²^ORCID,Dereure Olivier²³^ORCID,Drumez Elodie²⁴,Mortier Laurent²⁵²⁶^ORCID,Battistella Maxime¹¹²⁷^ORCID,Jouary Thomas¹^ORCID

Affiliation:

1. Dermatology Department CH Pau Pau France

2. Dermatology Department CHU Bordeaux Bordeaux France

3. Dermatology Department Hospices Civils de Lyon Pierre Bénite France

4. INSERM 1052, CNRS 5286, Centre Léon Bérard, Cancer Research Center of Lyon Université de Lyon, Université Claude Bernard Lyon 1 Lyon France

5. University Medical Research Unit (UMR) 1312, Bordeaux Institute of Oncology, Team 5 Translational Research on Oncodermatology and Orphean Skin Diseases University of Bordeaux Bordeaux France

6. Dermatology Department Oncopole Toulouse France

7. Department of General and Oncologic Dermatology Ambroise Paré Hospital, APHP Boulogne‐Billancourt France

8. EA 4340 “Biomarkers in Cancerology and Hemato‐Oncology”, UVSQ Université Paris‐Saclay Boulogne‐Billancourt France

9. Dermatology Department Cochin Hospital, APHP Paris France

10. Université Paris Cite, Dermato‐Oncology and CIC AP‐HP Hôpital Saint Louis, Cancer Institute APHP. Nord‐Université Paris Cite Paris France

11. INSERM U976 HIPI Saint‐Louis Hospital Paris France

12. Dermatology Department Hôpital Henri Mondor Créteil France

13. Dermatology Department Centre Léon Bérard, Cancer Research Center of Lyon Lyon France

14. Dermatology Department APHM La Timone Marseille France

15. Dermatology Department CHU Amiens‐Picardie Amiens France

16. Department of Dermatology APHP, Hôpital Avicenne University Hospital Bobigny France

17. UMRS‐11 24, Campus Paris Saint‐Germain‐Des‐Prés Paris University Paris France

18. Dermatology Department CHU Nancy Nancy France

19. Dermatology Department CHRU Strasbourg Strasbourg France

20. Dermatology Department CHU Nantes Nantes France

21. Dermatology Department APHP Bichat Paris France

22. Dermatology Department CHU Dijon Dijon France

23. Dermatology Department CHU Montpellier Montpellier France

24. Biostatistics Department CHU Lille Lille France

25. Dermatology Department, CHU Lille Lille France

26. Inserm U1189, Lille University Lille France

27. Université Paris Cite, Pathology Department, AP‐HP Hôpital Saint Louis, Cancer Institute APHP. Nord‐Université Paris Cite Paris France

Abstract

AbstractBackgroundCutaneous adnexal carcinomas are a heterogeneous group of rare neoplasms. Surgical excision is the first‐line treatment in localized stage. The use and effectiveness of radiotherapy have not been thoroughly evaluated in these neoplasms.ObjectivesThe present work analyses prognostic factors on outcomes in skin adnexal carcinomas, based on data from the CARADERM (CAncers RAres DERMatologiques) database.MethodsData were collected retrospectively including demographic data, tumour types and therapeutic characteristics of all patients included in the CARADERM database, with at least one informative follow‐up visit. Analyses were performed on three populations: patients with complete resection of the primary tumour (ADJ/primary population), patients achieving complete remission after complete resection of a recurrent tumour (ADJ/recurrent population) and patients with unresectable locally advanced or metastatic tumours (ADV/MET population). Overall and recurrence/progression‐free survivals at 3‐year were analysed using Cox regression models.ResultsRadiotherapy did not affect overall survival (OS) in the ADJ/primary population. Adjusted recurrence‐free survival (RFS) was significantly lower in the radiotherapy group in ADJ/primary group. Older patients had significantly poorer OS and RFS. Tumour size and immunosuppression were significantly associated with poorer RFS only. Radiotherapy had no effect on OS and RFS in the ADJ/recurrent population. Age was the only factor associated with a poorer OS. Radiotherapy was significantly associated with longer progression‐free survival (PFS) in age‐sex adjusted analysis in the ADV/MET population, without effect on OS.ConclusionsOur study shows that age, tumour size and immunosuppression are significantly associated with survival in localized adnexal carcinomas. Radiotherapy may improve PFS in the ADV/MET population but not in localized and recurrent carcinomas after complete excision.

Publisher

Wiley

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/jdv.20155

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