Validating the GTP-cyclohydrolase 1-feedback regulatory complex as a therapeutic target using biophysical andin vivoapproaches

Author:

Hussein D1,Starr A1,Heikal L1,McNeill E2,Channon K M2,Brown P R3,Sutton B J3,McDonnell J M3,Nandi M1

Affiliation:

1. Institute of Pharmaceutical Science; Faculty of Life Sciences & Medicine; King's College London; London UK

2. British Heart Foundation Centre of Research Excellence, Division of Cardiovascular Medicine; University of Oxford; John Radcliffe Hospital; Oxford UK

3. The Randall Division of Cell and Molecular Biophysics; Faculty of Life Sciences & Medicine; King's College London; London UK

Funder

British Heart Foundation

The Royal Society

Ministry of Higher Education, Saudi Arabia

Publisher

Wiley

Subject

Pharmacology

Reference39 articles.

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3. Zinc plays a key role in human and bacterial GTP cyclohydrolase I;Auerbach;PNAS,2000

4. Tetrahydrobiopterin attenuates superoxide-induced reduction in nitric oxide;Bowers;Front Biosci (Schol Ed),2011

5. Methods to detect nitric oxide and its metabolites in biological samples;Bryan;Free Radic Biol Med,2007

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