Regulatory approval and a first-in-human phase I clinical trial of a monoclonal antibody produced in transgenic tobacco plants

Author:

Ma Julian K-C.1,Drossard Jürgen23,Lewis David1,Altmann Friedrich4,Boyle Julia5,Christou Paul67,Cole Tom1,Dale Philip8,van Dolleweerd Craig J.1,Isitt Valerie1,Katinger Dietmar9,Lobedan Martin23,Mertens Hubert23,Paul Mathew J.1,Rademacher Thomas23,Sack Markus23,Hundleby Penelope A. C.8,Stiegler Gabriela9,Stoger Eva23,Twyman Richard M.10,Vcelar Brigitta9,Fischer Rainer23

Affiliation:

1. Molecular Immunology Unit; Institute for Infection and Immunity; St. George's University of London; London UK

2. Fraunhofer IME; Aachen Germany

3. RWTH Aachen University; Aachen Germany

4. Department of Chemistry; Universität für Bodenkultur (BOKU); Vienna Austria

5. Clinical Research Centre; Institute of Biosciences and Medicine; Faculty of Health & Medical Sciences; University of Surrey; Guildford Surrey UK

6. Department of Plant Production and Forestry Science; ETSEA; University of Lleida-Agrotecnio Center; Lleida Spain

7. Institució Catalana de Recerca i Estudis Avançats; Passeig Lluís Companys 23; Barcelona Spain

8. John Innes Centre; Norwich Research Park; Norwich UK

9. Polymun Scientific Immunbiologische Forschung GmbH; Klosterneuburg Austria

10. TRM Ltd; York UK

Funder

European Union for the Pharma-Planta project

CoMoFarm

COST Action Molecular Farming

Grand Challenges in Global Health

Wellcome Trust

ERC advanced grant Future-Pharma

Fraunhofer Gesellschaft

Publisher

Wiley

Subject

Plant Science,Agronomy and Crop Science,Biotechnology

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