<scp>HLA</scp>‐lacking clones in aplastic anaemia: Adaptive or maladaptive?-Reference-Cited by-同舟云学术

HLA‐lacking clones in aplastic anaemia: Adaptive or maladaptive?

Published:2024-08-26 Issue: Volume: Page:
ISSN:0007-1048
Container-title:British Journal of Haematology
language:en
Short-container-title:Br J Haematol

Author:

Gurnari Carmelo¹²^ORCID,Lima Alberto Cardoso Martins³⁴,Pagliuca Simona⁵⁶^ORCID

Affiliation:

1. Department of Biomedicine and Prevention University of Rome Tor Vergata Rome Italy

2. Department of Translational Hematology and Oncology Research, Cleveland Clinic Taussig Cancer Institute Cleveland Ohio USA

3. Histocompatibility Laboratory—Complexo Hospital de Clínicas Federal University of Paraná Curitiba PR Brazil

4. Immunogenetics Institute—Igen Associação Fundo de Incentivo à Pesquisa (AFIP) São Paulo SP Brazil

5. Department of Hematology Nancy University Hospital Nancy France

6. UMR 7365, IMoPA Lorraine University, CNRS Vandœuvre‐lès‐Nancy France

Abstract

HLA loss represents the result of immune forces shaping bone marrow clonal dynamics in immune aplastic anaemia. Human leukocyte antigen (HLA)‐deficient clones may rescue haematopoiesis by evading immune attacks, potentially guiding treatment strategies.Commentary on: Zaimoku et al. Haematopoietic regeneration by HLA‐A*0206‐deficient clones in severe aplastic anaemia without definitive immunosuppressive treatment. Br J Haematol 2024 (Online ahead of print). doi: 10.1111/bjh.19712.

Publisher

Wiley

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/bjh.19731

Reference10 articles.

1. Clonal evolution in aplastic anemia: failed tumor surveillance or maladaptive recovery?

2. HLA associations, somatic loss of HLA expression, and clinical outcomes in immune aplastic anemia

4. Molecular landscape of immune pressure and escape in aplastic anemia

5. Clinical and Molecular Determinants of Clonal Evolution in Aplastic Anemia and Paroxysmal Nocturnal Hemoglobinuria