Salivary microbiota and metabolic phenotype of patients with recurrent aphthous ulcers

Author:

Dong Yunmei1ORCID,Lou Fangzhi1,Yan Li1,Luo Shihong1,Zhang Yingying1,Liu Yang1,Lv Shiping1,Xu Jingyi1,Kang Ning1,Luo Zhuoyan1,Liu Yiyun2,Pu Juncai2,Ji Ping1,Jin Xin1ORCID

Affiliation:

1. Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences, College of Stomatology Chongqing Medical University Chongqing China

2. NHC Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases The First Affiliated Hospital of Chongqing Medical University Chongqing China

Abstract

AbstractObjectivesRecurrent aphthous ulcer (RAU) is a prevalent oral mucosal disease, affecting around 20% of the global population. It can greatly impair the quality of life for affected individuals. However, the exact etiology of RAU remains unknown.Subjects and Methods16S rRNA sequencing (16S rRNA‐seq) and non‐targeted liquid chromatography‐mass spectrometry (LC–MS) were employed to investigate the salivary microbiota and metabolic phenotype between RAU patients (N = 61) and healthy controls (HCs) (N = 105).ResultsFindings from 16S rRNA ‐seq indicated reduced oral microbial diversity in RAU patients compared to HCs, but increased interactions. Clinical variables did not show any significant association with the overall diversity of oral microbiota in RAU patients. However, significant correlations were observed between specific microorganisms and clinical variables. LC–MS results revealed dysregulation of amino acid, lipid, nucleotide, and caffeine metabolism in RAU patients. Furthermore, correlation analysis of 16S rRNA‐seq and LC–MS data revealed a significant association between salivary microbiota and metabolites in RAU patients.ConclusionsOur study revealed notable differences in salivary microbiota and metabolic profiles between RAU patients and HCs, indicating a strong link between oral microbiota dysbiosis, metabolic disturbances, and the onset and progression of RAU.

Funder

Natural Science Foundation of Chongqing

Publisher

Wiley

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