Do adventitious viruses carried by insect cell lines producing AAV vectors pose a safety risk in gene therapy?
Author:
Affiliation:
1. Hirszfeld Institute of Immunology and Experimental Therapy; Wroclaw Poland
2. Polish Hemophilia Society; Warsaw Poland
Publisher
Wiley
Subject
Genetics (clinical),Hematology,General Medicine
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1111/hae.13525/fullpdf
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3. Gene therapy with adeno-associated virus vector 5-human factor IX in adults with hemophilia B;Miesbach;Blood,2018
4. Long-term correction of canine hemophilia B by gene transfer of blood coagulation factor IX mediated by adeno-associated viral vector;Herzog;Nat Med,1999
5. Stable gene transfer and expression of human blood coagulation factor IX after intramuscular injection of recombinant adeno-associated virus;Herzog;Proc Natl Acad Sci U S A,1997
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