Affiliation:
1. Microbial Chemistry, Department of Chemistry – Ångström Uppsala University Uppsala SE Sweden
2. Plant Based Foods and Biochemistry, Food Analytics and Biotechnology, Department of Food Science University of Copenhagen Denmark
Abstract
AbstractThe looming climate crisis has prompted an ever‐growing interest in cyanobacteria due to their potential as sustainable production platforms for the synthesis of energy carriers and value‐added chemicals from CO2 and sunlight. Nonetheless, cyanobacteria are yet to compete with heterotrophic systems in terms of space‐time yields and consequently production costs. One major drawback leading to the low production performance observed in cyanobacteria is the limited ability to utilize the full capacity of the photosynthetic apparatus and its associated systems, i.e. CO2 fixation and the directly connected metabolism. In this review, novel insights into various levels of metabolic regulation of cyanobacteria are discussed, including the potential of targeting these regulatory mechanisms to create a chassis with a phenotype favorable for photoautotrophic production. Compared to conventional metabolic engineering approaches, minor perturbations of regulatory mechanisms can have wide‐ranging effects.
Funder
Carl Tryggers Stiftelse för Vetenskaplig Forskning
Novo Nordisk Fonden
Energimyndigheten
Cited by
3 articles.
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