Affiliation:
1. Second Clinical Medical College Henan University of Traditional Chinese Medicine Zhengzhou China
2. Department of Hepatobiliary and Gastroenterology Henan Provincial Hospital of Traditional Chinese medicine Zhengzhou China
Abstract
AbstractBackgroundObservational studies have shown an association between skin microbiota and alopecia areata (AA), but the causal connection remains ambiguous.MethodsWe obtained data on skin microbiota and AA from summary statistics of Genome‐Wide Association Studies and applied statistical methods from Mendelian randomization (MR) to assess causal relationships. Additionally, we investigated whether the skin microbiota acts as a mediator in the pathway from gut microbiota to AA.ResultsIn the MR analysis of KORA FF4 and AA, the inverse‐variance weighting method indicated that Corynebacterium (odds ratio [OR] = 0.82, 95% confidence interval [CI]: 0.70–0.96, p = 0.02) and asv037 (OR = 0.87, 95% CI: 0.76–0.99, p = 0.05) exerted protective effects, while Betaproteobacteria (OR = 1.21, 95% CI: 1.01–1.44, p = 0.03), asv015 (OR = 1.27, 95% CI: 1.05–1.54, p = 0.02), and Burkholderiales (OR = 1.20, 95% CI: 1.04–1.38, p = 0.01) were identified as risk factors in AA. In the MR analysis of PopGen and AA, asv001 (OR = 1.12, 95% CI: 1.01–1.24, p = 0.04), asv054 (OR = 1.13, 95% CI: 1.01–1.25, p = 0.03), and asv059 (OR = 1.14, 95% CI: 1.02–1.27, p = 0.02) were found to potentially increase the risk in AA. Furthermore, in the influence of gut microbiota on AA, the skin microbiota did not act as a mediator.ConclusionOur analysis suggests potential causal relationships between certain skin microbiota and AA, revealing insights into its pathogenesis and potential intervention strategies.
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献