Applications of engineered exosomes in drugging noncoding RNAs for cancer therapy-Reference-Cited by-同舟云学术

Applications of engineered exosomes in drugging noncoding RNAs for cancer therapy

Published:2023-07-26 Issue:5 Volume:102 Page:1257-1275
ISSN:1747-0277
Container-title:Chemical Biology & Drug Design
language:en
Short-container-title:Chem Biol Drug Des

Author:

Alemi Forough¹,Sadeghsoltani Fatemeh¹,Fattah Khashayar²,Hassanpour Parisa¹,Malakoti Faezeh¹,Kardeh Sina³,Izadpanah Melika¹,de Campos Zuccari Debora Aparecida Pires⁴,Yousefi Bahman¹^ORCID,Majidinia Maryam⁵^ORCID

Affiliation:

1. Department of Clinical Biochemistry and Laboratory Medicine, School of Medicine Tabriz University of Medical Sciences Tabriz Iran

2. School of Medicine Shahid Beheshti University of Medical Sciences Tehran Iran

3. Central Clinical School Monash University Melbourne Australia

4. Molecular Investigation of Cancer Laboratory (MICL) Faculdade de Medicina de São José do Rio Preto (FAMERP) São José do Rio Preto Brazil

5. Solid Tumor Research Center, Cellular and Molecular Medicine Institute Urmia University of Medical Sciences Urmia Iran

Abstract

AbstractNoncoding RNAs (ncRNAs) are engaged in key cell biological and pathological events, and their expression alteration is connected to cancer progression both directly and indirectly. A huge number of studies have mentioned the significant role of ncRNAs in cancer prevention and therapy that make them an interesting subject for cancer therapy. However, there are several limitations, including delivery, uptake, and short half‐life, in the application of ncRNAs in cancer treatment. Exosomes are introduced as promising options for the delivery of ncRNAs to the target cells. In this review, we will briefly discuss the application and barriers of ncRNAs. After that we will focus on exosome‐based ncRNAs delivery and their advantages as well as the latest achievements in drugging ncRNAs with exosomes.

Publisher

Wiley

Subject

Molecular Medicine,Biochemistry,Drug Discovery,Pharmacology,Organic Chemistry

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/cbdd.14300

Reference167 articles.

1. p53 induces formation of NEAT1 lncRNA-containing paraspeckles that modulate replication stress response and chemosensitivity

2. Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

3. Non-coding RNA networks in cancer

4. Induction of Lymphocyte Apoptosis by Tumor Cell Secretion of FasL-bearing Microvesicles

5. Exo-circRNAs: a new paradigm for anticancer therapy