Recent progress in the development of ursolic acid derivatives as anti‐diabetes and anti‐cardiovascular agents-Reference-Cited by-同舟云学术

Recent progress in the development of ursolic acid derivatives as anti‐diabetes and anti‐cardiovascular agents

Published:2023-09-13 Issue:6 Volume:102 Page:1643-1657
ISSN:1747-0277
Container-title:Chemical Biology & Drug Design
language:en
Short-container-title:Chem Biol Drug Des

Author:

Dai Yili¹^ORCID,Sun Linjun²,Tan Yan¹,Xu Wenyu¹,Liu Shu¹,Zhou Jing¹,Hu Yalin¹,Lin Jieying¹,Yao Xu¹,Mi Pengbing¹,Zheng Xing¹²

Affiliation:

1. Institute of Pharmacy and Pharmacology, Hengyang Medicinal School University of South China Hengyang China

2. Department of Pharmacy Hunan Vocational College of Science and Technology Changsha China

Abstract

AbstractUrsolic acid (UA) is a pentacyclic triterpenoid, which exhibits many biological activities, particularly in anti‐cardiovascular and anti‐diabetes. The further application of UA is greatly limited due to its low bioavailability and poor water solubility. Up to date, various UA derivatives have been designed to overcome these shortcomings. In this paper, the authors reviewed the development of UA derivatives as the anti‐diabetes anti‐cardiovascular reagents.

Publisher

Wiley

Subject

Molecular Medicine,Biochemistry,Drug Discovery,Pharmacology,Organic Chemistry

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/cbdd.14347

Reference39 articles.

1. Dietary 23-hydroxy ursolic acid protects against diet-induced weight gain and hyperglycemia by protecting monocytes and macrophages against nutrient stress-triggered reprogramming and dysfunction and preventing adipose tissue inflammation

2. Catharanthus roseus Combined with Ursolic Acid Attenuates Streptozotocin-Induced Diabetes through Insulin Secretion and Glycogen Storage

3. The molecular mechanisms underpinning the therapeutic properties of oleanolic acid, its isomer and derivatives for type 2 diabetes and associated complications

4. The anti-tumor effect of ursolic acid on papillary thyroid carcinoma via suppressing Fibronectin-1

5. Synthesis, biological evaluation and SAR studies of ursolic acid 3β-ester derivatives as novel CETP inhibitors

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