Combination of Pharmacophore Matching, 2D Similarity Search, andIn VitroBiological Assays in the Selection of Potential 5-HT6Antagonists from Large Commercial Repositories-Reference-Cited by-同舟云学术

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Combination of Pharmacophore Matching, 2D Similarity Search, andIn VitroBiological Assays in the Selection of Potential 5-HT6Antagonists from Large Commercial Repositories

Published:2015-04-30 Issue:4 Volume:86 Page:864-880
ISSN:1747-0277
Container-title:Chemical Biology & Drug Design
language:en
Short-container-title:Chem Biol Drug Des

Author:

Dobi Krisztina¹,Flachner Beáta¹,Pukáncsik Mária¹,Máthé Enikő¹,Bognár Melinda¹,Szaszkó Mária¹,Magyar Csaba²,Hajdú István¹²,Lőrincz Zsolt¹,Simon István²,Fülöp Ferenc³,Cseh Sándor¹,Dormán György¹

Affiliation:

1. Targetex Kft.; Kápolna köz 4/a Dunakeszi H-2120 Hungary

2. Institute of Enzymology; Research Centre for Natural Sciences; Hungarian Academy of Sciences; Magyar Tudósok körútja 2. Budapest H-1117 Hungary

3. Institute of Pharmaceutical Chemistry; University of Szeged; Eötvös u. 6. Szeged H-6720 Hungary

Funder

National Development Agency (NFÜ)

Research and Technology Innovation Fund

Országos Tudományos Kutatási Alapprogramok

Publisher

Wiley

Subject

Molecular Medicine,Biochemistry,Drug Discovery,Pharmacology,Organic Chemistry

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1111/cbdd.12563/fullpdf

Reference55 articles.

1. Medicinal chemistry strategies to 5-HT(6) receptor ligands as potential cognitive enhancers and antiobesity agents;Holenz;Drug Discov Today,2006

2. Selective 5-HT6 receptor ligands: progress in the development of a novel pharmacological approach to the treatment of obesity and related metabolic disorders;Heal;Pharmacol Ther,2008

3. International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (Serotonin);Hoyer;Pharmacol Rev,1994

4. Classification and nomenclature of 5-HT receptors: a comment on current issues;Hoyer;Behav Brain Res,1996

5. 5-ht6 receptors;Woolley;Curr Drug Targets CNS Neurol Disord,2004

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1. Rapid Identification of Potential Drug Candidates from Multi-Million Compounds’ Repositories. Combination of 2D Similarity Search with 3D Ligand/Structure Based Methods and In Vitro Screening;Molecules;2021-09-15

2. The Serotonergic System;Chemical Biology of Neurodegeneration;2019-08-09

3. A novel identification approach for discovery of 5-HydroxyTriptamine 2A antagonists: combination of 2D/3D similarity screening, molecular docking and molecular dynamics;Journal of Biomolecular Structure and Dynamics;2018-03-05

4. Computational Modeling of Drugs for Alzheimer’s Disease: Design of Serotonin 5-HT6 Antagonists;Neuromethods;2017-09-28

5. Drug Design for CNS Diseases: Polypharmacological Profiling of Compounds Using Cheminformatic, 3D-QSAR and Virtual Screening Methodologies;Frontiers in Neuroscience;2016-06-10

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