microRNA let-7g suppresses PDGF-induced conversion of vascular smooth muscle cell into the synthetic phenotype

Author:

Wang Tzu-Ming1ORCID,Chen Ku-Chung2,Hsu Po-Yuan1,Lin Hsiu-Fen3,Wang Yung-Song45,Chen Chien-Yuan16,Liao Yi-Chu78,Juo Suh-Hang H.191011

Affiliation:

1. Department of Medical Research; China Medical University Hospital; Taichung Taiwan

2. Department of Biochemistry and Molecular Cell Biology; School of Medicine; College of Medicine; Taipei Medical University; Taipei Taiwan

3. Department of Neurology; Kaohsiung Medical University; Kaohsiung Taiwan

4. Department of Life Science; National Taiwan University; Taipei Taiwan

5. Institute of Fisheries Science; National Taiwan University; Taipei Taiwan

6. Graduate Institute of Medicine; Kaohsiung Medical University; Kaohsiung Taiwan

7. Department of Neurology; National Yang-Ming University School of Medicine; Taipei Taiwan

8. Department of Neurology; Taipei Veterans General Hospital; Taipei Taiwan

9. Graduate Institute of Biomedical Sciences; China Medical University; Taichung Taiwan

10. Institute of New Drug Development; China Medical University; Taichung Taiwan

11. Brain disease research center; China Medical University; Taichung Taiwan

Funder

Ministry of Science and Technology

National Health Research Institutes

Publisher

Wiley

Subject

Cell Biology,Molecular Medicine

Reference33 articles.

1. Atherosclerotic plaque destabilization: mechanisms, models, and therapeutic strategies;Silvestre-Roig;Circ Res,2014

2. NDRG2 induced by oxidized LDL in macrophages antagonizes growth factor productions via selectively inhibiting ERK activation;Liu;Biochim Biophys Acta,2010

3. Acceleration of matrix metalloproteinase-1 production and activation of platelet-derived growth factor receptor beta in human coronary smooth muscle cells by oxidized LDL and 4-hydroxynonenal;Akiba;Biochim Biophys Acta,2006

4. Proteoglycan distribution in lesions of atherosclerosis depends on lesion severity, structural characteristics, and the proximity of platelet-derived growth factor and transforming growth factor-beta;Evanko;Am J Pathol,1998

5. Mechanism of action and in vivo role of platelet-derived growth factor;Heldin;Physiol Rev,1999

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