Phase I/II study exploring ImMucin, a pan-major histocompatibility complex, anti-MUC1 signal peptide vaccine, in multiple myeloma patients

Author:

Carmon Lior1,Avivi Irit23,Kovjazin Riva1,Zuckerman Tsila23,Dray Lillian4,Gatt Moshe E.4,Or Reuven4,Shapira Michael Y.4

Affiliation:

1. Vaxil BioTherapeutics Ltd.; Nes-Ziona Israel

2. Department of Haematology; Rambam Medical Campus; Haifa Israel

3. Technion; Israel Institute of Technology; Haifa Israel

4. Department of Bone Marrow Transplantation & Cancer Immunotherapy; Hadassah Medical Centre; Jerusalem Israel

Publisher

Wiley

Subject

Hematology

Reference39 articles.

1. Cancer-associated MUC1 mucin inhibits human T-cell proliferation, which is reversible by IL-2;Agrawal;Nature Medicine,1998

2. Targeting tumour cells with defects in the MHC Class I antigen processing pathway with CD8 +  T cells specific for hydrophobic TAP- and Tapasin-independent peptides: the requirement for directed access into the ER;Aladin;Cancer Immunology, Immunotherapy,2007

3. Coinhibitory molecule PD-1 as a potential target for the immunotherapy of multiple myeloma;Atanackovic;Leukemia,2014

4. Lenalidomide maintenance after stem-cell transplantation for multiple myeloma;Attal;New England Journal of Medicine,2012

5. Lenalidomide maintenance after stem-cell transplantation for multiple myeloma: follow-up analysis of the IFM 2005-02 trial;Attal;Blood (ASH Annual Meeting Abstracts),2013

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