Comparative effectiveness of various noninvasive local treatments in patients with epistaxis: A systematic review and network meta‐analysis

Author:

Chiang Cheng‐Ying1,Lin Jen‐Shyang1,Tsai Tou‐Yuan23,Tu Yu‐Kang45,Tsai Ming‐Jen1ORCID

Affiliation:

1. Department of Emergency Medicine Ditmanson Medical Foundation Chia‐Yi Christian Hospital Chiayi Taiwan

2. Department of Emergency Medicine, Dalin Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Chiayi Taiwan

3. School of Medicine Tzu Chi University Hualien Taiwan

4. Institute of Epidemiology and Preventive Medicine, College of Public Health National Taiwan University Taipei Taiwan

5. Department of Dentistry, National Taiwan University Hospital and School of Dentistry National Taiwan University Taipei Taiwan

Abstract

AbstractBackgroundThe best initial strategy for managing epistaxis is unclear. We performed a systematic review and network meta‐analysis (NMA) to compare the effectiveness of various noninvasive treatments for patients with epistaxis.MethodsWe searched PubMed, Embase, and the Cochrane Library from inception to September 2022 without language restrictions. Randomized controlled trials (RCTs) assessing immediate hemostasis, 2‐day and 7‐day rebleeding outcomes, as well as the use of noninvasive interventions for the treatment of epistaxis were selected. Frequentist NMA was performed.ResultsThe systematic review included 20 RCTs (2994 participants) involving 12 different interventions. The NMA demonstrated that topical treatment with tranexamic acid (TXA) significantly reduced the odds of 2‐day rebleeding compared with the control conservative treatment (odds ratio [OR] 0.36, 95% confidence interval [CI] 0.21–0.61) and traditional anterior nasal packing (OR 0.45, 95% CI 0.26–0.76). The sensitivity analysis yielded robust results, and the overall evidence was high. Topical TXA significantly reduced the odds of 7‐day rebleeding compared with traditional nasal packing (OR 0.33, 95% CI 0.15–0.70), with moderate evidence owing to the heterogeneous results. Despite the significant effects of topical TXA on achieving immediate hemostasis and Rapid Rhino nasal packing on preventing 2‐day rebleeding compared to the control and traditional nasal packing, the evidence is low to very low due to heterogeneity, inconsistency, and within‐study bias.ConclusionsIn the treatment of epistaxis, topical TXA may be superior to conservative treatment or traditional nasal packing, particularly in preventing 2‐day rebleeding.

Publisher

Wiley

Subject

Emergency Medicine,General Medicine

Cited by 2 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Toxicity Following Tranexamic Acid Overdose;Journal of Medical Toxicology;2024-02-09

2. Neusbloeding/epistaxis;Kleine Kwalen in de huisartsenpraktijk;2023-11-14

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