Greater hyperthermia in men with type 2 diabetes does not lead to higher serum levels of cellular stress biomarkers following exercise-heat stress-Reference-Cited by-同舟云学术

Greater hyperthermia in men with type 2 diabetes does not lead to higher serum levels of cellular stress biomarkers following exercise-heat stress

Published:2024-06-01 Issue:6 Volume:49 Page:874-879
ISSN:1715-5312
Container-title:Applied Physiology, Nutrition, and Metabolism
language:en
Short-container-title:Appl. Physiol. Nutr. Metab.

Author:

Goulet Nicholas¹²^ORCID,Tetzlaff Emily J.¹^ORCID,McCormick James J.¹^ORCID,King Kelli E.¹^ORCID,Janetos Kristina-Marie T.¹^ORCID,Sigal Ronald J.¹³⁴^ORCID,Boulay Pierre⁵^ORCID,Kenny Glen P.¹⁴^ORCID

Affiliation:

1. Human and Environmental Physiology Research Unit, School of Human Kinetics, Faculty of Health Sciences, University of Ottawa, Ottawa, ON, Canada

2. Behavioural and Metabolic Research Unit, School of Human Kinetics, Faculty of Health Sciences, University of Ottawa, Ottawa, ON, Canada

3. Departments of Medicine, Cardiac Sciences, and Community Health Sciences, Cumming School of Medicine, Faculties of Medicine and Kinesiology, University of Calgary, Calgary, AB, Canada

4. Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada

5. Faculty of Physical Activity Sciences, University of Sherbrooke, Sherbrooke, QC, Canada

Abstract

Type 2 diabetes (T2D) is associated with worsening age-related impairments in heat loss, causing higher core temperature during exercise. We evaluated whether these thermoregulatory impairments occur with altered serum protein responses to heat stress by measuring cytoprotection, inflammation, and tissue damage biomarkers in middle-aged-to-older men (50–74 years) with ( n = 16) and without ( n = 14) T2D following exercise in 40°C. There were no changes in irisin, klotho, HSP70, sCD14, TNF-α, and IL-6, whereas NGAL (+539 pg/mL, p = 0.002) and iFABP (+250 pg/mL, p < 0.001) increased similarly across groups. These similar response patterns occurred despite elevated core temperature in individuals with T2D, suggesting greater heat vulnerability.

Funder

Canadian Institutes of Health Research

Institut du Savoir Montfort

Natural Sciences and Engineering Research Council of Canada

Human and Environmental Physiology Research Unit

University of Ottawa

Mitacs Accelerate Fellowship

Publisher

Canadian Science Publishing

Link

https://cdnsciencepub.com/doi/pdf/10.1139/apnm-2023-0599

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