Combined use of NMR, distance geometry, and restrained energy minimization for the conformational analysis of 8-lysine–vasopressin

Abstract

The conformation of the neurohypophyseal hormone, 8-lysine–vasopressin, in DMSO solution has been determined from 2D-NMR and distance geometry followed by the restrained energy minimization calculation. The conformation of 8-lysin–vasopressin in the 20-membered ring region is well defined but the acyclic tripeptide tail region is disordered.